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Inventi Impact: Biomedical Analysis

Articles

  • Inventi:pba/28554/19
    Modulatory Effect of Guinep (Melicoccus bijugatus\nJacq) Fruit Pulp Extract on Isoproterenol-Induced\nMyocardial Damage in Rats. Identification of Major\nMetabolites Using High Resolution UHPLC\nQ-Orbitrap Mass Spectrometry
    Research 2019 : April - June
    Chukwuemeka R Nwokocha, Isheba Warren, Javier Palacios, Mario Simirgiotis, Magdalene Nwokocha, Sharon Harrison, Rory Thompson, Adrian Paredes, Jorge Borquez, Astrid Lavado, Fredi Cifuentes

    Guinep is traditionally used in the management of cardiovascular ailments. This study\naims to evaluate its medicinal constituents and effects in the management of myocardial injury in\nan experimental isoproterenol (ISO) rat model. Sprague-Dawley rats were randomly assigned to four\ngroups: Group 1 was the control group; Group 2 received M. bijugatus extract (100 mg/Kg; MB) for\nsix weeks; Group 3 was given ISO (85 mg/Kg) i.p. twice during a 24-hour period; and Group 4 was\ngiven ISO (85 mg/Kg) i.p. and MB extract (100 mg/Kg) for six weeks. The MB was administered\norally by gavage, daily. The blood pressure of conscious animals was measured, while ECG was\nperformed under anesthesia. Blood and serum were collected for biochemical and hematological\nanalysis. The ISO group treated with MB showed a significant decrease.........

    How to Cite this Article
    CC Compliant Citation: Nwokocha, Chukwuemeka R., et al. \"Modulatory Effect of Guinep (Melicoccus bijugatus Jacq) Fruit\nPulp Extract on Isoproterenol-Induced Myocardial Damage in Rats. Identification of Major Metabolites Using High\nResolution UHPLC Q-Orbitrap Mass Spectrometry.\" Molecules 24.2 (2019): 235, doi:10.3390/molecules24020235, http://\ncreativecommons.org/licenses/by/4.0/.
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